EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.138 | additional information | MtDH transcript increases after treatment with tobacco leaf extract | Alternaria alternata | |
1.1.1.138 | additional information | transcript of both MtDH and MPDH start to increase by 30 min after the addition of tobacco extract, reaching 2.5fold to almost 4fold higher by 2 h. No increase in transcript for MtDH and MPDH if cultures are treated with water instead of tobacco leaf extract | Alternaria alternata |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.17 | additional information | construction of a disruption mutant, that shows elevated levels of trehalose, but is viable, and the conidia germinate normally, the mutant is less pathogenic in infected tobacco plants compared to the wild-type fungus, overview | Alternaria alternata |
1.1.1.138 | additional information | MtDH mutant produces less mannitol than compared to the wild-type. The MtDH/MPDH double mutant does not produce mannitol. Response of the genes in the disruption mutants is similar to that in wild-type. Conidia of mutants are viable and germinated normally. Elevated levels of trehalose in the mutants, suggesting that trehalose may substitute for mannitol as a storage compound for germination. Tobacco inoculation shows no reduction in lesion severity caused by the MtDH mutant as compared with wild-type, whereas the MtDH/MPDH double mutant causes significantly less disease. The double mutant is unaffected in the ability to germinate and produce appressoria on tobacco leaves and elicites a defense response from the host, indicating that it is able to penetrate and infect the host | Alternaria alternata |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.17 | D-mannitol 1-phosphate + NAD+ | Alternaria alternata | the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview | D-fructose 6-phosphate + NADH + H+ | - |
r | |
1.1.1.17 | D-mannitol 1-phosphate + NAD+ | Alternaria alternata A5 | the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview | D-fructose 6-phosphate + NADH + H+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.17 | Alternaria alternata | - |
- |
- |
1.1.1.17 | Alternaria alternata A5 | - |
- |
- |
1.1.1.138 | Alternaria alternata | - |
- |
- |
1.1.1.138 | Alternaria alternata A5 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.17 | D-mannitol 1-phosphate + NAD+ | - |
Alternaria alternata | D-fructose 6-phosphate + NADH + H+ | - |
r | |
1.1.1.17 | D-mannitol 1-phosphate + NAD+ | the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview | Alternaria alternata | D-fructose 6-phosphate + NADH + H+ | - |
r | |
1.1.1.17 | D-mannitol 1-phosphate + NAD+ | - |
Alternaria alternata A5 | D-fructose 6-phosphate + NADH + H+ | - |
r | |
1.1.1.17 | D-mannitol 1-phosphate + NAD+ | the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview | Alternaria alternata A5 | D-fructose 6-phosphate + NADH + H+ | - |
r | |
1.1.1.138 | D-mannitol + NAD(P)+ | - |
Alternaria alternata | D-fructose + NAD(P)H + H+ | - |
? | |
1.1.1.138 | D-mannitol + NAD(P)+ | - |
Alternaria alternata A5 | D-fructose + NAD(P)H + H+ | - |
? | |
1.1.1.138 | D-mannitol + NADP+ | - |
Alternaria alternata | D-fructose + NADPH + H+ | - |
r | |
1.1.1.138 | D-mannitol + NADP+ | - |
Alternaria alternata A5 | D-fructose + NADPH + H+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.17 | mannitol 1-phosphate 5-dehydrogenase | - |
Alternaria alternata |
1.1.1.17 | MPDH | - |
Alternaria alternata |
1.1.1.138 | MtDH | - |
Alternaria alternata |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.17 | NAD+ | - |
Alternaria alternata | |
1.1.1.17 | NADH | - |
Alternaria alternata | |
1.1.1.138 | NADP+ | - |
Alternaria alternata |